If you’re open to taking Hemp oil, chances are you’re wondering, “How long does it take for Hemp oil to work?” and “How long does Hemp oil last in your system?” It’s a tricky question, though. There is no one concrete answer. How Hemp will work for you, and how long it stays in your system, is up to a variety of factors, from tolerance and weight to method of consumption and dosage.

How Does Hemp Work?

How Hemp interacts with your endocannabinoid system is a large piece of the puzzle when it comes to finding the answer to questions like “ How long does it take for Hemp oil to work? ” or “How fast does Hemp oil work?”

Hemp, short for cannabidiol, is one of the compounds found in the cannabis plant. However, it’s often mistaken for another compound, tetrahydrocannabinol (THC), which is responsible for the psychological “high” many users associate with cannabis. Hemp will not get you high; however, it does work with your body’s endocannabinoid system to provide natural benefits.

Hemp interacts with a range of proteins in both the body and central nervous system, with a critical piece taking place within the ECS. The CB1 and CB2 cannabinoid receptors are largely responsible for interacting with the Hemp. One property of Hemp is its inhibition of the absorption of anandamide, a natural cannabinoid that regulates pain. Hemp also interacts with other receptor proteins, such as serotonin-receptor 5-HT1A and vanilloid receptor TRPV1. Although there still is much research to be done on Hemp and evidence sought after, many people believe it’s purported anti-inflammatory and pain-relieving benefits could be a result of these activations and interactions.

Methods of Consumption

Methods of Consumption

There also are a few ways to consume Hemp oil, and this is another puzzle piece. Before you ask, “ How long does it take for Hemp oil to work? ”, you should consider how you will use the product. Hemp oil can be consumed in its pure form, inhaled, or even applied topically. Pure Relief offers a few different Hemp-derived products that you can look into for yourself and determine what works best for you.


One way to consume Hemp oil is to put a few drops directly into your mouth. While this is both the quickest and easiest to consume it, quickly swallowing the oil also prevents Hemp from immediately entering the bloodstream. Rather than absorb straight into the bloodstream, your body will first send it through the digestive tract and to the liver.

The liver breaks the Hemp down before it reaches the bloodstream, sending it instead through the digestive tract and eventually on to the liver, where the Hemp’s concentration is reduced before finally reaching the bloodstream.

The same goes for Hemp-infused edibles, such as brownies or Hemp gummies, and even adding a few drops of Hemp oil to whatever you’re cooking. All ultimately will go through the digestive tract, reducing the total Hemp concentration in your bloodstream. It’s a lengthy process, and it also means Hemp could take a couple of hours to set in.


Similar to ingestion, Hemp oil can be consumed sublingually. The user simply places a few drops under the tongue and holds it there for 30 seconds or so before swallowing it. With this method, however, Hemp is absorbed by the mucous membranes located in the mouth and allows the body to skip over the initial metabolization process. This means Hemp will enter your bloodstream more quickly, reducing the amount of time it takes to feel its effects.


If you hope the answer to the question “How long does it take for Hemp oil to work?” is sooner rather than later, inhalation is probably one of the quickest ways to reap the effects of Hemp. This includes smoking a high-Hemp strain or using a Hemp vape pen.

When Hemp is smoked or vaped, the cannabinoids are sent directly to the lungs and rapidly absorbed into the bloodstream. That means it reaches peak concentration within minutes after consumption, making it one of the most effective ways to reap the effects of Hemp quickly.


Topical Hemp is applied directly to and absorbed through the skin, interacting with localized cannabinoid receptors. Hemp topicals come in the form of creams and lotions and typically are used to help alleviate localized and even chronic pain. When Hemp is applied topically, it can take up to an hour or two to feel its full effects.

Other Factors

Method of consumption often plays a significant role in determining how long does it take for Hemp oil to work -- and how long it will stay in your system -- but there are other factors that can have an effect on how Hemp interacts with your body.


Just as with alcohol, your weight can determine how Hemp affects you. How much body fat you have plays a role in the amount of Hemp needed to work effectively. Someone who weighs more likely will require more Hemp to achieve their desired results. This also affects how long Hemp remains in the system.


Have you ever been annoyed by someone who seems to eat like crazy and never gains a pound? Your metabolism also helps determine how long Hemp stays in your system. The faster the metabolism, the shorter the amount of time Hemp stays in your system. Likewise, if you have a slower metabolism, it likely will last longer.


Above all, you want to make sure you’re taking the correct dosage for your needs. It’s best to consult with a doctor or healthcare provider to decide on the ideal Hemp dosage for your treatment. Plus, the dosage amount impacts how long Hemp stays in your system. It always is recommended to start with a low dosage and, if needed, gradually increase it until desired results are achieved.


In summary, the answer to the question of “How long does it take for Hemp oil to work?” is a weighted one. Depending on various factors, from the method of consumption and dosage to weight and metabolism, the time it takes for Hemp to take effect in the body -- and how long it remains in the body -- can differ from person to person. When first starting on your journey with Hemp products, it’s best to be conservative with dosage and consider your method of consumption. You know your body best, so pay attention to what it’s telling you and adjust your Hemp needs accordingly.

May 11, 2020