Understanding the Endocannabinoid System

Understanding the Endocannabinoid System

You’re probably heard about the circulatory system and the limbic system, but recently, scientists have discovered the endocannabinoid system. So, what is the endocannabinoid system? And how does CBD stimulate this system? Here’s everything you need to know about the endocannabinoid system. 

What Is the Endocannabinoid System? 

What Is the Endocannabinoid System?  The endocannabinoid system is a system of receptors within the human body that was first discovered in the 1990s when scientists first began to examine the potential positive effects of marijuana and its components. Since then, experts have partially mapped the endocannabinoid system and have figured out some of its functions.  Researchers are working to figure out all of the various possible applications for the endocannabinoid system and are trying to gain more information about it. Because this system has only been discovered recently, it will take some time before the effects of the endocannabinoid system are fully understood.

Why Did It Take So Long to Discover the Endocannabinoid System? 

The endocannabinoid system was discovered only a few decades ago and is only beginning to be taught in schools. So, what took so long? There are several potential reasons.  The first reason is that marijuana had a reputation during the 1800s as being a ‘bad drug.’ While marijuana had been used as an herbal remedy worldwide for centuries, marijuana and the hemp plant both gained a negative reputation when they began to compete with cotton. It was said that marijuana was only smoked by people who were lazy and criminals. This led to several local and federal marijuana restrictions until it was officially classified as a Schedule 1 drug by the DEA in the 1970s.  Another potential reason for the recent discovery of the endocannabinoid system is that, while we know a lot about the human body, there is always more to learn. 

What Does the Endocannabinoid System Control? 

While scientists are still exploring the endocannabinoid system, a few of its functions have been identified. When stimulated or suppressed, the endocannabinoid receptors play a role in mood, memory, appetite, and even sleep. 

What Are the Components of the Endocannabinoid System? 

The endocannabinoid system comprises three main parts: the receptors, the enzymes, and the endocannabinoids. The receptors are located in different areas throughout our body and serve as a binding site for the endocannabinoids. Thus far, two significant receptors have been identified- CB1 and CB2. While CB1 primarily acts on the nervous system, controlling coordination, appetite, mood, memory, and other functions, CB2 receptors act on the peripheral nervous system, which influences the sensation of pain and inflammation.  The enzymes serve to break down cannabinoids to help ensure that they can interact with the receptors. Meanwhile, endocannabinoids are natural substances found in the body that are part of homeostasis, meaning that they keep the body running well and efficiently. For instance, the endocannabinoids NADA and 2-AG help in regulating various physiological functions of the body.  It’s worth noting that the body makes these chemicals regardless of whether or not one ingests CBD or marijuana. 

What Happens When There Is Not Enough Endocannabinoids? 

Lack of endocannabinoids has been linked to various conditions, including chronic pain, psoriasis, fibromyalgia, Parkinson’s, chronic anxiety, depression, and even PTSD. A natural deficiency of endocannabinoids has been named Clinical Endocannabinoid Deficiency Syndrome (CECD). The discovery of CECD has opened up new potential for treatments for these disorders and other conditions that are currently being researched. 

What is CBD? 

CBD is one of the two major components that has been isolated from marijuana, while THC is the other. While THC has been found to cause the “high’ effect that is often associated with marijuana use, CBD has been found to activate the endocannabinoid system because it is similar to the endocannabinoids naturally produced within the body. 

What Are the Benefits of CBD? 

Because CBD acts on the endocannabinoid system, it can have several potential positive implications. Research is ongoing about CBD’s applications for pain, anxiety, depression, and other disorders. If you are considering CBD for a health condition, we encourage you to speak to your doctor first to ensure that CBD is a safe option in your specific case because, like other natural substances, it can interact with medications. 

Is CBD Legal Everywhere? 

Unfortunately, due to the longstanding bias against marijuana, some states have anti-CBD and anti-marijuana laws on the books. Likewise, CBD is also technically illegal on a federal level because there is no CBD product that is currently FDA approved for use. Before you explore CBD and marijuana use, you should ensure that it is a legal option in your state. 

Where Can One Get CBD?

There are several places that one can get CBD, including online. Whether you’re shopping in-store or online, it is important to ensure that you are shopping from a reliable source like Pure Relief to ensure that your CBD is sourced safely and ethically.  However, keep in mind that if CBD is restricted in your state, online retailers will likely want you to present a medical card and ID. Likewise, if CBD is illegal in your state, online retailers may not be able to ship CBD to you at all. 

The Future of the Endocannabinoid System and CBD

Scientists continue to explore the endocannabinoids system and, with that, continue to gain proof of the potential benefits of CBD. Meanwhile, pro-CBD and pro-marijuana groups continue to work towards the legalization of both CBD and marijuana. With time, CBD may become a treatment option for various health conditions. 

Takeaways

  • The endocannabinoid system is a system that exists within our bodies that was discovered in the 1970s.
  • The system is composed of receptors, enzymes, and endocannabinoids. 
  • Endocannabinoids can bind receptors in the central and peripheral nervous systems regulating sleep, mood, and other things.
  • Lack of endocannabinoids or CECD is linked to several disorders, including PTSD and depression.
  • Endocannabinoids are produced naturally in the body but can also be found in CBD. 
  • CBD is a non-psychoactive component of marijuana.
July 07, 2021 — admin
A Complete Look at CBD Oil's Potential Side Effects

A Complete Look at CBD Oil's Potential Side Effects

CBD has been gaining popularity as a potential treatment for a variety of ailments and is currently being researched for other helpful properties. However, CBD, like other natural substances, is not without its side effects. Here is what you need to know.

What Is CBD, Exactly? 

What Is CBD, Exactly?  CBD stands for cannabidiol, a substance that is one of the components derived from hemp and marijuana plants. Unlike tetrahydrocannabinol or THC, the chemical that causes the ‘high’ feeling, CBD doesn’t make users feel high but instead activates various receptors within the body. 

A Bit About the History of CBD

Cannabis and marijuana have often been associated with ‘getting high’ and have had a bad reputation for some time. However, hemp plants have been used in traditional medicine for centuries. Around the 1980s, scientists began taking an interest in the potential benefits of hemp and marijuana, which is when CBD and THC were first isolated. The research also led to the mapping of a system of receptors called the endocannabinoid system.

Ongoing Research 

CBD has been the topic of research for several years, and researchers are continuing to explore the potential benefits of CBD and other cannabis components today. While some uses for CBD have been backed by several studies, others are based on anecdotal evidence. We will be covering all potential benefits and potential side effects of CBD, some of which are still being researched at this time. 

What Are the Potential Benefits of CBD?

CBD can be used to relieve various ailments and symptoms, including nausea, poor appetite, anxiety, and insomnia. CBD products may also potentially:  While CBD has many potential uses, many of the above are still being carefully investigated by the scientific community. 

Is CBD Regulated? 

No, and that is perhaps why it is important to pay attention to the potential side effects. While CBD has increasingly been legalized across the U.S., it is not regulated by the FDA. This means that manufacturers often make their own formulation with variable percentages. Fortunately, most good manufacturers will list the dosage information, including the recommended dosage, on the bottle. This is also why you should ensure that you are purchasing your CBD oil from a reliable manufacturer. 

What Are the Common Side Effects of CBD?

CBD has several common potential side effects that can result from either a sensitivity to CBD or from taking the incorrect dosage. The most common side effects include: 
  • Drowsiness and Sedation: Because CBD helps you relax, it can also make you feel sleepy. Feeling too relaxed and sleepy, however, is not always ideal. If you are worried about experiencing drowsiness following CBD use, we recommend avoiding driving and other attention-intensive tasks when taking CBD and for several hours afterward. Of course, the feeling of sleepiness can also be a benefit for those who use CBD as a sleep aid.  
  • Gastrointestinal Issues: CBD may cause diarrhea and liver problems, especially when taken with certain medications. If you are taking other medications or have underlying medical conditions, it is recommended that you speak to your doctor before taking CBD. 
  • Dry Eyes and Cottonmouth: CBD is associated with dry eyes and dry mouth, also known as cottonmouth. While these two side effects are more strongly associated with THC, they may also occur with CBD. 
  • Drug Interactions: While CBD is a natural substance, it can interact with your other medications and, in some cases, cause serious side effects, which is why speaking to your doctor is essential before you incorporate CBD into your daily routine. 
  • Nausea: While CBD can be used to promote appetite, nausea is also a potential side effect. Nausea seems to be more common in people who take CBD supplements or people who ingest too much CBD. 

Less Common Side Effects and Precautions Associated with CBD

Below are some less common side effects and other things to keep in mind when taking CBD. 
  • Pregnancy and Breastfeeding: CBD has not been proven safe when taken by women who are pregnant or breastfeeding. In fact, CBD is classified as “possibly unsafe” for women who are pregnant or breastfeeding. 
  • Children: CBD is considered possibly safe for children, especially when used as CBD oil. One of the early applications for CBD as a potential treatment was for children with a specific kind of epilepsy. When used as a treatment for children, CBD should be prescribed by a healthcare professional, and the child’s condition should be monitored per the doctor’s orders. There is no evidence that commercial CBD presents an effective treatment. 
  • Liver Disease: Because the liver plays a key role in metabolism, people with liver disease may not be able to take regular doses of CBD. Instead, they should opt for a lower dosage and consult their healthcare provider before using CBD. 
  • Individuals With Parkinson’s: Parkinson's patients who took CBD oil reported that high doses of CBD exacerbate their tremors and make movement more difficult. 

Tips for Safely Taking CBD Oil

Here are a few tips to ensure that you are safely taking CBD: 

Follow the Manufacturer Dosage Guidelines

While the concentration of CBD in the oil can vary depending on the brand, most manufacturers will offer a recommended dosage so that their clients do not take a higher-than-recommended dose of CBD. 

Start Small, Start Safe

If you are new to CBD, we recommend taking the minimum dosage, or even half of the minimum dosage if you think you are sensitive. If you have been prescribed CBD by a healthcare provider, we recommend following that healthcare provider’s instructions.  We also recommend that you give yourself some time in case you happen to experience one of the common side effects, such as drowsiness. Plan to take CBD when you have the opportunity to rest and even sleep if the need arises. 

Speak to Your Doctor

Speak to your doctor about your plan to try CBD oil and make sure that the CBD will not interact with your existing medications. Again, people with liver disease need to take extra precautions with CBD. 

Takeaways

  • CBD oils, edibles, and other products are still being explored as a potential treatment for a variety of conditions.
  • The most common side effects of CBD are nausea, upset stomach, dry mouth and eyes, and drowsiness.
  • Always speak to your healthcare provider before using CBD.
June 09, 2021 — admin
True or False: Does CBD Get You High?

True or False: Does CBD Get You High?

False! CBD does not get you high. If you are considering getting into CBD products, you may have some questions, such as: Can CBD get you high? What does CBD oil feel like? These are all valid questions since CBD products are extracted from cannabis plants. Read on to find out more about CBD and how it interacts with your body.

Effects of CBD on Your Body? 

Effects of CBD on Your Body? 

Our bodies naturally produce neurotransmitters called endocannabinoids. These neurotransmitters bind to cannabinoid receptors in your nervous system, including the brain. When CBD (external endocannabinoids) enters the body, its interaction and stimulation of the endocannabinoid system promote homeostasis in the body, helping reduce the inflammatory response and the sensation of pain. 

Will CBD Get You High?

CBD is non-intoxicating, meaning it will never get you high, even if you tried your hardest. Full-spectrum CBD oils like Pure Relief's Mint Oil are formulated to purposely incorporate the complete cannabinoid profile to give you full access to the benefits. 

However, full-spectrum CBD products must be manufactured in strict compliance with federal regulations, which require that they have less than 0.3% THC. This means you never have to worry about severe, unwanted intoxicating effects. So, does CBD give you a high? No, think of it as a runner’s high; it’s more of a whole-body experience.

Full-spectrum CBD allows you to experience what is called the “entourage effect.” This is the theory that suggests that small traces of THC and CBD work better when taken together than when taken alone. 

Of course, there are also less potent products generally termed “broad-spectrum.” These CBD products contain a range of other cannabinoids (remember there are hundreds), but no THC. These provide most of the benefits of the entourage effect minus the risk of testing positive for any trace of THC.

CBD and Drug Testing

You may wonder, if full-spectrum CBD products contain traces of THC, will consuming some make you fail a drug test? The answer is, it’s very unlikely. 

As explained by VeryWellHealth, CBD oil is derived from hemp cannabis, rather than marijuana, which has very limited THC. In the cases of testing positive on drug tests, the CBD product is more likely to have been bought from a dispensary or local store, than a trustworthy online seller. Most of the time, what happens is that these dispensaries mislead users by lying about the contents of the products. You may think that you're getting a broad spectrum oil with no THC when, in fact, the product might contain higher levels of THC than you may have realized. 

If you work in a place that conducts random drug tests, you can set your mind at ease with taking a CBD product from a manufacturer who commits to transparency. Know what's in your CBD product!

CBD and Drug Testing

What Is the Difference Between CBD and THC?

CBD doesn’t target the same cannabinoid receptors as THC. There are different types of cannabinoids, each having different interactions with our endocannabinoid system. 

So, if CBD doesn’t get you high, what exactly does CBD feel like? Rather than giving you a euphoric sensation, the main effect attributed to CBD products is a sense of calm and relaxation. Instead of a specific emotion like the happy feeling associated with getting high, there is usually the decrease of unpleasant emotions and states, including anxiety, discomfort, and insomnia.

Those who have switched to vape pens might be wondering if CBD vape oil will get them high. If this is your excuse for getting into CBD products, think again. Like any other CBD product, vaping CBD will not have the effect you might be chasing.  

CBD Products and Getting High: A Summary

The remarkable versatility of CBD products makes them quite useful for numerous conditions. If you're eager to know how CBD makes you feel, the only answer is to try it.  

So, can CBD oil get you high? No, the effects of CBD on the brain and central nervous system function are mild. CBD products are verified as safe, non-habit forming, and relaxing rather than any feeling of being under the influence. If you are concerned about drug screenings, you can set your mind at peace by using a THC-free formula. 
For the purest and legal CBD products, look for trustworthy brands that are fully transparent about their extraction processes. Leading CBD brands like Pure Relief go the extra mile for their customers by having their formulas tested by third-party laboratories to ensure they are 100% compliant with all industry standards and regulations.

June 11, 2020 — admin
CBD Isolate vs. Full Spectrum CBD: Understanding the Difference

CBD Isolate vs. Full Spectrum CBD: Understanding the Difference

If you are new to CBD, there are many things you need to consider before making your first purchase. One of the most important choices that you will need to make when choosing a CBD product is whether to go with full-spectrum CBD or isolate CBD. Even though both types of CBD extract offer significant benefits, understanding the difference between these two types of CBD is crucial to experience the best results.

What Is CBD Extract?

CBD, also known as cannabidiol, is one of the dozens of organic compounds found in hemp. In recent years, CBD has been proven to have an array of medicinal benefits such as relieving pain, alleviating anxiety, and promoting sleep. In fact, CBD is so effective and has become so popular among medical professionals and their patients that it is now being extracted and manufactured into products like oils, edibles, and creams.  

Is Full Spectrum Hemp Oil Legal?

The 2018 Farm Bill legalized hemp in the United States last December. The bill established different norms and regulations that benefit the hemp industry including removing hemp from the federal list of controlled substances and taking away the DEA’s power to treat hemp as an illicit drug.

Industrial hemp is now classified as an agricultural commodity and is regulated by the Department of Agriculture and individual state agencies. The bill has encouraged many to look into hemp-derived CBD as a medicinal supplement and/or financial investment since experts project the CBD industry will surpass the $20 billion mark in the next four years.

Is Full Spectrum Hemp Oil Legal?

CBD Full Spectrum vs Isolate: What’s the Difference?

When searching for CBD products online, you will often come across the terms full-spectrum and isolate. These define the content of hemp products. Learning about these two main types of hemp products will help you make a smarter choice when purchasing CBD online.

What Is CBD Isolate?

CBD isolate is a crystalline powder containing 99% pure cannabidiol from hemp. All other components of the hemp plant are removed to achieve pure CBD extracts. Pure CBD isolate is obtained through a purification process where all plant material minus CBD is filtered out of the extracts. After filtration, the extracted substance goes through a more rigorous process called winterization.

Winterization removes all remaining elements that might have stuck around after filtration. This leaves a fine, white powder consisting of only CBD.

How to Use CBD Isolate?

The white powder known as CBD isolate is entirely odorless and tasteless. Because of its lack of taste and odor, users around the world have learned to use CBD isolate in a variety of ways.

By far the easiest and most effective way to take CBD isolate is through sublingual consumption. Simply, place a dose of CBD isolate under your tongue and hold it there for 30 to 60 seconds. This allows the CBD to be absorbed by the capillaries under your tongue which deliver CBD directly to your bloodstream.

Since CBD isolate is 100% tasteless, it also makes for the perfect additive to your foods and drinks. Try it in smoothies, acai bowls, or your morning coffee. You can also use isolate powder in baked goods like cakes, cookies, and brownies. A daily dose of CBD isolate in your foods is the best way to benefit from the properties of CBD in a delicious and familiar way.

What is Full Spectrum CBD?

As opposed to CBD isolate, full-spectrum CBD contains a combination of all other cannabinoids found in hemp. However, only minimal amounts of these cannabinoids are included in a full spectrum solution– CBD is still the main ingredient. Some compounds in full-spectrum CBD include CBN (cannabinol), CBG (cannabigerol), and THC (tetrahydrocannabinol). Even though THC is often included in full-spectrum solutions, it comes in very low concentrations (less than 0.3%), resulting in no psychoactive effects.

What Is Broad Spectrum CBD?

Another common term you may come across in your CBD journey is broad-spectrum CBD, a term often erroneously used in place of full-spectrum CBD. So, what is the difference between broad-spectrum and full-spectrum CBD products?

As the name implies, broad-spectrum CBD contains more compounds than just CBD. However, unlike full spectrum CBD, its formulas do not contain all compounds found in hemp.

What Are the Benefits of Full Spectrum CBD?

As mentioned before, both isolate and full-spectrum CBD offers numerous benefits. It was previously believed that products made with pure CBD were more potent than full spectrum CBD.  However, recent studies suggest full and broad-spectrum formulas may provide stronger relief over time because of the entourage effect.

The Entourage Effect

This phenomenon refers to the way different cannabinoids work together to deliver more potent benefits than one specific cannabinoid alone. Traces of cannabis compounds like CBN, CBG, and terpenes enhance the effects of CBD due to these compounds also having significant medicinal properties. Broad and full-spectrum formulas even contain THC (tetrahydrocannabinol) which can also help improve how CBD works without causing any psychoactive effects.

How to Use Full Spectrum CBD

Like pure CBD isolate, full-spectrum CBD is also extremely versatile. Dozens of brands online offer full-spectrum products like full-spectrum CBD oil, CBD gummies, capsules, and even beverages. Most importantly, brands selling broad and full-spectrum CBD products today have close to zero percent THC in their formulas, meaning they are completely safe and legal.

How Is CBD Extracted?

Compounds from hemp, such as CBD, can be extracted using different methods; however, the best by far is CO2 extraction.

CO2 extraction refers to a method that uses pressurized carbon dioxide (CO2) to create a highly concentrated form of CBD that is suitable for human consumption. This process pulls the desired phytochemicals like CBD out of the plant material isolating the substance and forming an extract that is free of harmful chemicals, fertilizers, and other undesired substances.

How Does the CO2 Extraction Method Work?

Under certain conditions, carbon dioxide acts like a solvent that is capable of creating a variety of end products. By manipulating temperature and pressure, manufacturers use this method to force CO2 into a state that is somewhere between liquid and gas. This state is known as a “supercritical” state.

In its supercritical state, CO2 works as a highly effective extraction solvent that has been used for years by food companies. For example, supercritical CO2 extraction is used to remove caffeine from coffee and extract essential oils from plants.

When it comes to CBD extraction, supercritical CO2 is passed through a high-tech chamber where it pulls all of the desired chemicals (in this case CBD) out of the plant material. After the CBD is extracted with supercritical CO2, the temperature is changed back to room temperature, so all the CO2 evaporates leaving behind a substance that contains no solvents or unwanted chemicals.

Pure CBD Provides Pure Relief

Supercritical CO2 extraction is the industry’s best practice for pure CBD extraction. However, this method requires top-of-the-line high-tech equipment making it an expensive alternative to other less effective extraction methods used by many CBD companies.

If you are considering CBD for your daily routine, it is essential to buy from a CBD company like Pure Relief that gets the extracts through supercritical CO2 extraction. All Pure Relief products are made using CBD obtained through supercritical CO2 extraction. Additionally, our products are formulated by a pharmacist with years of experience in the industry ensuring each CBD item in our collection is safe for your consumption.

October 28, 2019 — admin