Hemp-derived Hemp has gained notoriety for its ample range of medicinal uses and no side effects. We use Hemp oil for neurological disorders, depression, some types of cancer, even for insomnia and weight loss. But, does the lack of significant side effects mean Hemp is entirely safe when taken with other medications?

Here’s all you need to know about Hemp drug interactions.

The Cytochrome P450 System

To understand how Hemp oil may interact with other substances in your system, you must first understand what the cytochrome P450 system is and the role it plays.

The cytochrome P450 system, found within the liver, consists of enzymes that process and eliminate potentially toxic compounds. The P450 enzyme system is responsible for metabolizing over 60% of all pharmaceuticals.

Can Hemp Oil Interact with Medications I’m Taking?

Research shows that Hemp may interfere with the P450 system’s ability to metabolize other drugs. When you consume Hemp, it inhibits the system’s ability to metabolize compounds found in pharmaceutical, drugs meaning drugs can stay in your system longer. This can pose several risks especially if you are taking powerful painkillers like oxycodone and fentanyl.

Hemp and CYP3A4 Enzyme

It’s important to note that Hemp does not interact with every CYP450 enzyme. Most Hemp interactions occur via a specific CYP enzyme called CYP3A4. The way CYP3A4 metabolizes Hemp varies significantly from one person to another as a result of variations in our DNA makeup. In addition to Hemp, drugs metabolized by CYP3A4 include:

  • Xanax
  • Lipitor
  • Claritin
  • Prednisone
  • Fentanyl
  • Viagra
  • Cialis
  • Ambien
  • Topamax

If you are taking any of these drugs, consult with a doctor before introducing Hemp products to your daily regimen.

Hemp and CYP2C19 Interactions

Research has shown that Hemp inhibits CYP2C19 enzymes in the cytochrome P450 complex. This enzyme is responsible for metabolizing many proton pump inhibitors and antiepileptic drugs such as risperidone, pantoprazole, and clobazam.

Taking high doses of Hemp can interfere with the degradation of these drugs leading to their increased bioavailability. This was shown in a two-month-long clinical study where patients were treated for epilepsy with clobazam and Hemp. The Hemp interaction with CYP3A4 and CYP2C19 led to increased clobazam bioavailability.

Researchers believe this same phenomenon can occur when taking other drugs that are metabolized by CYP2C19 enzymes. Again, if you are currently taking any medication, you should consult with a doctor first before beginning a Hemp regimen.

Hemp Oil and Blood Thinners

If you are taking Hemp, you should pay particular attention to blood thinner medications like warfarin. Mixing Hemp products with blood thinners can make the blood thinner stay in your system for too long without being broken down, increasing the risk of potentially harmful side effects.

Hemp and Adderall Interaction

CBD and Adderall Interaction

Adderall is commonly prescribed for conditions like narcolepsy, attention deficit disorder (ADD), and attention deficit hyperactivity disorder (ADHD). The unregulated use of Adderall is also common among college students, who find Adderall helpful in improving their ability to concentrate and overall productivity. However, Adderall has side effects like fatigue, depression, and anxiety, especially as the impact of the drug begins to wear off.

Due to its calming effects, Hemp can reduce the effects of Adderall, creating a more balanced feeling if the effects of the drug are too strong. However, using Hemp during the comedown may cause excessive fatigue and feelings of relaxation.

Hemp Interactions with Other Drugs

Any drug that is metabolized by the cytochrome p450 system may interact with Hemp. These include:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta-blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

How to Dose Hemp

One major factor determining how Hemp may interact with other medications in your system is the potency of your daily dose. Stronger doses of Hemp may stay in your body longer, thus interacting with the cytochrome P450 system for longer, as well. To ensure you are not taking a stronger dose than needed, start your Hemp regimen with a relatively small dose and work your up slowly until you achieve the desired results.

Seek Professional Advice

For the most effective and safest Hemp consumption practices, use pharmacist formulated Hemp from a trusted Hemp manufacturer and consult with your physician if you are taking any other medications. Using high-quality Hemp with professional guidance will help you make the most of your Hemp routine.

October 28, 2019